Comparison of the peak inotropic effects of a catecholamine and a digitalis glycoside in the intact canine heart.
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چکیده
منابع مشابه
Studies on digitalis. 13. A comparison of the effects of potassium on the inotropic and arrhythmia-producing actions of ouabain.
Although it is generally recognized that digitalis-induced arrhythmias can be suppressed by the administration of potassium (1-3), it is not clear whether the potassium ion also influences the positive inotropic effect exerted by the glycosides on the intact mammalian heart. Clarification of this problem is important in the understanding of the interrelationships between the actions of glycosid...
متن کاملProtection from digitalis toxicity with the prophylactic use of diphenylhydantoin sodium. An arrhythmic-inotropic dissociation.
Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%. At constant heart rates, pretreatment with diphenylhydantoin sodium did not alter the elevation of rate of rise of left ventricular pressure produced by the glycoside. Two implications have been drawn from these findings. First, the inotropic and arrhythmic act...
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Light is important for the production of metabolites by plant cell culture. It is therefore necessary to evaluate the light conditions with respect to exposure time. Both enhancement and inhibition have been observed depending on exposure time and species. Callus culture of D. nervosa was established and effect of light and passage on cardiac glycoside production was studied. In vitro cultures ...
متن کاملEffect of light and passage on cardiac glycoside production on cultured cell of Digitalis nervosa Steud & Hochst
Light is important for the production of metabolites by plant cell culture. It is therefore necessary to evaluate the light conditions with respect to exposure time. Both enhancement and inhibition have been observed depending on exposure time and species. Callus culture of D. nervosa was established and effect of light and passage on cardiac glycoside production was studied. In vitro cultures ...
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OPC-18790 is a positive inotropic and vasodilating agent that increases intracellular cyclic AMP and stimulates Ca currents. We examined its direct electrophysiological effects in isolated blood-perfused canine cardiac preparations. OPC-18790 caused an acceleration of the intraventricular conduction in association with an increase of the contractile force and the coronary blood flow. We also ex...
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عنوان ژورنال:
- Circulation
دوره 42 5 شماره
صفحات -
تاریخ انتشار 1970